Aberrant insula activity to negative and reduced learning from positive feedback underlie maladaptive self-beliefs in depression

Authors

Nora Czekalla, Alexander Schröder, Annalina V. Mayer, Janine Stierand, David S. Stolz, Tobias Kube, Christoph W. Korn, Ines Wilhelm, Jan Philipp Klein, Frieder M. Paulus, Sören Krach & Laura Müller-Pinzler

Journal

Translational Psychiatry - Nature

Abstract

Maladaptive self-beliefs are a core symptom of major depressive disorder. These beliefs are perpetuated by a negatively biased integration of self-related feedback. Understanding the neurocomputational mechanisms of biased belief updating may help to counteract maladaptive beliefs and the maintenance of depression.

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Supporting media

Member authors

Ines Wilhelm-Groch

Project Leader

Sören Krach

Project Leader

Annalina Valpuri Mayer

Clinician Scientist

Research area

C04

Circadian regulation of cognitive biases during adolescence

Adolescent depression is linked to cognitive biases and circadian rhythm disruption. How these rhythms influence learning and mood is unclear. This project investigates their effect on socio-emotional learning biases and tests interventions to stabilize rhythms.