C04
Circadian regulation of cognitive biases during adolescence
Adolescent depression is linked to cognitive biases and circadian rhythm disruption. How these rhythms influence learning and mood is unclear. This project investigates their effect on socio-emotional learning biases and tests interventions to stabilize rhythms.
The mechanisms by which circadian disruption affects cognitive biases and depressive symptoms in adolescents are insufficiently understood.
Circadian regulation shapes socio-emotional learning; its disruption can worsen depressive tendencies.
We will assess how circadian rhythms impact cognitive biases and depressive symptoms, and test interventions to stabilize rhythms and improve mental health using behavioral, neurophysiological, and computational approaches.
The team for
C04
The publications of
C04
The circadian neurobiology of reward
January 10, 2023
Circadian clocks are important regulators of physiology and behavior. In the brain, circadian clocks have been described in many centers of the central reward system. They affect neurotransmitter signaling, neuroendocrine circuits, and the sensitivity to external stimulation. Circadian disruption affects reward signaling, promoting the development of behavioral and substance use disorders. In this review, we summarize our current knowledge of circadian clock-reward crosstalk. We show how chronodisruption affects reward signaling in different animal models. We then translate these findings to circadian aspects of human reward (dys-) function and its clinical implications. Finally, we devise approaches to and challenges in implementing the concepts of circadian medicine in the therapy of substance use disorders.
