Ines Wilhelm-Groch
Project Leader
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University of Lübeck
I'm Professor of Clinical Psychology at the University of Lübeck and Chief Psychologist at UKSH. My research investigates the role of sleep and circadian rhythms in mental disorders, with a focus on memory and emotion processing, PTSD, and the development of sleep- and chronobiology-based approaches to enhance psychological treatments.
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The projects of
Ines Wilhelm-Groch
C04
Circadian regulation of cognitive biases during adolescence
Circadian regulation of cognitive biases during adolescence
The publications of
Ines Wilhelm-Groch
Aberrant insula activity to negative and reduced learning from positive feedback underlie maladaptive self-beliefs in depression
August 6, 2026
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Translational Psychiatry - Nature
Maladaptive self-beliefs are a core symptom of major depressive disorder. These beliefs are perpetuated by a negatively biased integration of self-related feedback. Understanding the neurocomputational mechanisms of biased belief updating may help to counteract maladaptive beliefs and the maintenance of depression.
The circadian neurobiology of reward
January 10, 2023
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Acta Physiologica
Circadian clocks are important regulators of physiology and behavior. In the brain, circadian clocks have been described in many centers of the central reward system. They affect neurotransmitter signaling, neuroendocrine circuits, and the sensitivity to external stimulation. Circadian disruption affects reward signaling, promoting the development of behavioral and substance use disorders. In this review, we summarize our current knowledge of circadian clock-reward crosstalk. We show how chronodisruption affects reward signaling in different animal models. We then translate these findings to circadian aspects of human reward (dys-) function and its clinical implications. Finally, we devise approaches to and challenges in implementing the concepts of circadian medicine in the therapy of substance use disorders.
