Annalina Valpuri Mayer

Clinician Scientist

University of Lübeck

I’m a psychologist, psychotherapist in training, and neuroscientist at the Department of Psychiatry, University of Lübeck. My research explores the neural mechanisms underlying social experience and how these become dysfunctional in mental disorders. My current focus is the role of circadian rhythmicity in shaping self-image and learning biases, particularly in depression and low self-esteem.

The projects of

Annalina Valpuri Mayer

C04

Detecting

Targeting

Circadian regulation of cognitive biases during adolescence

Adolescent depression is linked to cognitive biases and circadian rhythm disruption. How these rhythms influence learning and mood is unclear. This project investigates their effect on socio-emotional learning biases and tests interventions to stabilize rhythms.

Circadian regulation of cognitive biases during adolescence

Adolescent depression is linked to cognitive biases and circadian rhythm disruption. How these rhythms influence learning and mood is unclear. This project investigates their effect on socio-emotional learning biases and tests interventions to stabilize rhythms.

The publications of

Annalina Valpuri Mayer

Targeting

Exploiting

Aberrant insula activity to negative and reduced learning from positive feedback underlie maladaptive self-beliefs in depression

August 6, 2026

Translational Psychiatry - Nature

Maladaptive self-beliefs are a core symptom of major depressive disorder. These beliefs are perpetuated by a negatively biased integration of self-related feedback. Understanding the neurocomputational mechanisms of biased belief updating may help to counteract maladaptive beliefs and the maintenance of depression.