Josef Priller
Project Leader
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Charité
I'm a neuropsychiatrist and Professor of Neuropsychiatry at Charité, where I direct the Department of Neuropsychiatry. I also direct the Department of Psychiatry and Psychotherapy at TUM and hold the Chair of Brain Inflammation and Repair at Edinburgh and the UK Dementia Research Institute. My research examines myeloid cells and microglia in neurodegenerative and neuropsychiatric disease.
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The projects of
Josef Priller
C02
Circadian immune dysfunction in prodromal stages of Alzheimer‘s disease
Circadian immune dysfunction in prodromal stages of Alzheimer‘s disease
The publications of
Josef Priller
Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease
March 31, 2023
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Acta Physiologica
Dysfunction of circadian and sleep rhythms is an early feature of many neurodegenerative diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive and psychiatric disturbances. Although it is largely unclear whether dysfunctions in sleep and circadian rhythms contribute to the etiology of AD or are a consequence of the disease, there is evidence that these conditions are involved in a complex self-reinforcing bidirectional relationship. According to the recent studies, dysregulation of the circadian clock already occurs during the asymptomatic stage of the disease and could promote neurodegeneration. Thus, restoration of sleep and circadian rhythms in preclinical AD may represent an opportunity for early intervention to slow the disease course.
Keywords: Alzheimer's disease; circadian system; clock; neurodegeneration; sleep.
