Josef Priller
Projektleiter
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Charité
Ich bin Neuropsychiater und Professor für Neuropsychiatrie an der Charité und leite dort die Abteilung für Neuropsychiatrie. Zudem leite ich die Klinik für Psychiatrie und Psychotherapie der TUM sowie den Lehrstuhl für Brain Inflammation and Repair in Edinburgh und am UK DRI. Meine Forschung gilt myeloiden Zellen und Mikroglia bei neurodegenerativen und neuropsychiatrischen Erkrankungen.
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Die Projekte von
Josef Priller
C02
Circadiane Immunstörungen im Prodromalstadium der Alzheimer-Krankheit
Circadiane Immunstörungen im Prodromalstadium der Alzheimer-Krankheit
Die Publikationen von
Josef Priller
Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease
March 31, 2023
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Acta Physiologica
Dysfunction of circadian and sleep rhythms is an early feature of many neurodegenerative diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive and psychiatric disturbances. Although it is largely unclear whether dysfunctions in sleep and circadian rhythms contribute to the etiology of AD or are a consequence of the disease, there is evidence that these conditions are involved in a complex self-reinforcing bidirectional relationship. According to the recent studies, dysregulation of the circadian clock already occurs during the asymptomatic stage of the disease and could promote neurodegeneration. Thus, restoration of sleep and circadian rhythms in preclinical AD may represent an opportunity for early intervention to slow the disease course.
Keywords: Alzheimer's disease; circadian system; clock; neurodegeneration; sleep.
