A04
Internal circadian desynchronization and its impact on immune regulation
Internal circadian desynchronization, common in shift work, jetlag, and clinical care, alters immune regulation. This project explores how cellular clock synchrony can be quantified and how their desynchrony affects inflammatory programs.
There is currently no robust method to quantify internal circadian desynchronization at the cellular level in humans.
Disruption of the coordinated circadian system affects immune programs, linking internal desynchrony to changes in inflammatory regulation across tissues.
We will develop single-sample assays to detect internal circadian desynchronization and relate it to immune regulatory states in mice and humans.
The team for
A04
