B02
Circadian desynchronization and epigenetic alteration crosstalk on the development and resolution of metabolic dysfunction-associated steatohepatitis
A coordinated circadian-epigenetic network maintains liver metabolic homeostasis. Disruption of circadian rhythms or epigenetic regulation alters metabolism and inflammation, contributing to steatohepatitis. This project explores their interaction.
The interplay between circadian disruption and epigenetic changes driving metabolic dysfunction-associated steatohepatitis remains unclear.
Circadian and epigenetic pathways jointly regulate liver metabolic and inflammatory programs; disruption rewires cell signaling, DNA methylation, and protein networks.
We will dissect crosstalk between circadian function and DNA methylation in liver metabolism using mouse models, hepatocyte cultures, organoids, and clinical cohorts, and evaluate interventions restoring homeostasis.
The team for
B02
