Targeting

Exploiting

Early but not late time-restricted eating improves an actigraphy-estimated sleep quality in women with overweight or obesity: secondary analysis of the crossover ChronoFast trial

Authors

Beeke Peters, Jennifer Jokisch, Julia Schwarz, Bettina Schuppelius, Andreas F. H. Pfeiffer, Andreas Michalsen, Achim Kramer and Olga Pivovarova-Ramich

Journal

Frontiers in Nutrition

Abstract

Metabolic disorders are closely linked to sleep disturbances. Timerestricted eating (TRE) can improve metabolic disturbances, but its impact onsleep quality is insufficiently studied and recommendations regarding the eatingtiming in TRE are pending. Our aim was to investigate the impact of early TRE(eTRE) and late TRE (lTRE) on sleep quality in obesity. This is a secondary analysis of the randomized crossover trial, whichincluded 31 women with overweight and obesity. Following a 2–4 week baselineperiod, participants were assigned to either a two-week eTRE (eating 8a.m−4p.m.) or a two-week lTRE (eating 1 p.m.−9 p.m.), separated by a two-weekwashout phase. Sleep metrics were assessed objectively by blinded actigraphyand subjectively using Pittsburgh Sleep Quality Index (PSQI) and self-reportof sleep quality. Hunger and satiety were examined using a Visual AnalogueScale (VAS). Actigraphy revealed no between-intervention differences in changesin sleep metrics, but improvements were observed within eTRE compared withbaseline for sleep efficiency (p = 0.047), sleep fragmentation index (SFI) (p= 0.029), and awakening length (p = 0.043). Individuals with lowest sleepquality at the baseline showed its largest improvements in eTRE. PSQI scoresand self-reported sleep quality remained unchanged between and within bothinterventions. There were no differences in evening hunger and satiety scoresbetween eTRE and lTRE, and no correlations between hunger or satiety andsleep quality

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Supporting media

Member authors

Research area

B01

Targeting

Circadian rhythms and chronotherapy in multiple sclerosis

Multiple sclerosis features disturbances in sleep, metabolism, and immune activity across the circadian cycle, which may actively contribute to disease activity. This project investigates how these rhythms influence disease progression and whether strengthening them can be therapeutically beneficial.

Circadian rhythms and chronotherapy in multiple sclerosis

Multiple sclerosis features disturbances in sleep, metabolism, and immune activity across the circadian cycle, which may actively contribute to disease activity. This project investigates how these rhythms influence disease progression and whether strengthening them can be therapeutically beneficial.